Position - Dependent Repression and Promotion of DQB 1 Intron

GGGG Motifs Intron 3 Splicing by DQB 1 Promotion of Position - Dependent Repression

GGGG Motifs Intron 3 Splicing by DQB 1 Promotion of Position - Dependent Repression and

Ddh334 3189..3202

We show that the allele-dependent expression of transcripts encoding soluble HLA-DQb chains is determined by branchpoint sequence (BPS) haplotypes in DQB1 intron 3. BPS RNAs associated with low inclusion of the transmembrane exon in mature transcripts showed impaired binding to splicing factor 1 (SF1), indicating that alternative splicing of DQB1 is controlled by differential BPS recognition ea...

Mechanisms of activation and repression by the alternative splicing factors RBFOX1/2.

RBFOX1 and RBFOX2 are alternative splicing factors that are predominantly expressed in the brain and skeletal muscle. They specifically bind the RNA element UGCAUG, and regulate alternative splicing positively or negatively in a position-dependent manner. The molecular basis for the position dependence of these and other splicing factors on alternative splicing of their targets is not known. We...

The pluripotency factor-bound intron 1 of Xist is dispensable for X chromosome inactivation and reactivation in vitro and in vivo.

X chromosome inactivation (XCI) is a dynamically regulated developmental process with inactivation and reactivation accompanying the loss and gain of pluripotency, respectively. A functional relationship between pluripotency and lack of XCI has been suggested, whereby pluripotency transcription factors repress the master regulator of XCI, the noncoding transcript Xist, by binding to its first i...